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Issue 4, 2016
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Facile synthesis of new N-sulfonamidyl-4-thiazolidinone derivatives and their biological evaluation

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Abstract

The one-pot three-component syntheses of new N-sulfonamide-thiazolidin-4-one derivatives were carried out in excellent yield using [HDBU][HSO4] as an ionic liquid under solvent-free conditions. The newly synthesized compounds were screened against fungal strains and a number of compounds were seen to display excellent antifungal activity. In addition, the synthesized compounds were screened for their scavenging activity of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and showed very good antioxidant activity. Finally, theoretical predictions derived from molecular docking studies against the potential target sterol 14α-demethylase (CYP51) helped establish a link between the observed biological activity and the binding affinity, thereby providing insights into the specific bonding and non-bonding interactions governing the activity.

Graphical abstract: Facile synthesis of new N-sulfonamidyl-4-thiazolidinone derivatives and their biological evaluation

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Publication details

The article was received on 04 Jan 2016, accepted on 18 Jan 2016 and first published on 04 Feb 2016


Article type: Paper
DOI: 10.1039/C6NJ00021E
New J. Chem., 2016,40, 3047-3058

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    Facile synthesis of new N-sulfonamidyl-4-thiazolidinone derivatives and their biological evaluation

    D. D. Subhedar, M. H. Shaikh, F. A. Kalam Khan, J. N. Sangshetti, V. M. Khedkar and B. B. Shingate, New J. Chem., 2016, 40, 3047
    DOI: 10.1039/C6NJ00021E

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