Jump to main content
Jump to site search

Issue 3, 2016
Previous Article Next Article

Synthesis and antiproliferative efficiency of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles

Author affiliations

Abstract

A new approach for the synthesis of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles has been developed. This method operates in a single step giving the products in good to excellent yields. Antiproliferative efficiency of the synthesized compounds was tested against HCT116 (colon cancer) and A549 (lung cancer) cell lines. Among them, compounds 3m (IC50, 9.7 μM) and 3h (IC50, 20.3 μM) were found to be the best antiproliferative agents.

Graphical abstract: Synthesis and antiproliferative efficiency of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles

Back to tab navigation

Supplementary files

Article information


Submitted
21 Oct 2015
Accepted
19 Jan 2016
First published
25 Jan 2016

New J. Chem., 2016,40, 2823-2828
Article type
Paper
Author version available

Synthesis and antiproliferative efficiency of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles

K. N. Nandeesh, H. A. Swarup, N. C. Sandhya, C. D. Mohan, C. S. Pavan Kumar, M. N. Kumara, K. Mantelingu, S. Ananda and K. S. Rangappa, New J. Chem., 2016, 40, 2823
DOI: 10.1039/C5NJ02925B

Social activity

Search articles by author

Spotlight

Advertisements