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Issue 3, 2016
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Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

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Abstract

A porphyrin monosubstituted by three triethyleneglycol chains grafted on a pentaerythritol skeleton was designed to display an optimized amphiphilicity for an enhanced cellular uptake and thus to exert enhanced photocytotoxicity. This porphyrin proved to be an excellent photosensitiser with submicromolar IC50.

Graphical abstract: Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

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Article information


Submitted
04 Oct 2015
Accepted
03 Dec 2015
First published
07 Dec 2015

New J. Chem., 2016,40, 2044-2050
Article type
Paper

Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

D. Topkaya, D. Lafont, F. Poyer, G. Garcia, F. Albrieux, P. Maillard, Y. Bretonnière and F. Dumoulin, New J. Chem., 2016, 40, 2044
DOI: 10.1039/C5NJ02716K

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