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Issue 6, 2016
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Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators

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Abstract

Metabolic syndrome (MetS) is a widespread, complex disease cluster which consists of hypertension, atherosclerosis, dyslipidaemia and type II diabetes. The treatment of MetS requires multiple pharmaceutical agents leading to complex polypharmacy. Multi-target compounds might reduce the number of required drugs in MetS patients. In this study we fused three different pharmacophores of soluble epoxide hydrolase (sEH) inhibitors and peroxisome proliferator-activated receptor (PPAR) agonists. The most promising fused scaffold exhibits multi-target activity and represents a valuable starting point for design and evaluation of fused sEH/PPAR modulators.

Graphical abstract: Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators

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Supplementary files

Article information


Submitted
19 Jan 2016
Accepted
10 Apr 2016
First published
22 Apr 2016

This article is Open Access

Med. Chem. Commun., 2016,7, 1209-1216
Article type
Research Article

Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators

R. Blöcher, C. Lamers, S. K. Wittmann, O. Diehl, T. Hanke, D. Merk, D. Steinhilber, M. Schubert-Zsilavecz, A. S. Kahnt and E. Proschak, Med. Chem. Commun., 2016, 7, 1209
DOI: 10.1039/C6MD00042H

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