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Issue 1, 2016
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Reconstruction and analysis of a genome-scale metabolic model for Eriocheir sinensis eyestalks

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Abstract

The eyestalk of Eriocheir sinensis has significant biological functions with many nerve peptide hormones expressed in the X-organ which exists in the eyestalk. A metabolic network model is an effective tool for the systematic study of E. sinensis eyestalks. In this work, we reconstructed a metabolic network model for E. sinensis eyestalks based on transcriptome sequencing. The model contains 1304 reactions, 1381 unigenes and 1243 metabolites distributing in 98 pathways. The reconstructed metabolic network model was used for the functional module and block metabolite analysis of eyestalks, which reveals that the function of the eyestalk network agrees with its function as the centre of the E. sinensis endocrine system. The difference expression analysis of reactions in the model indicates that the eyestalk mainly functions in the regulation of amino acids, carbohydrate and nucleotide metabolism.

Graphical abstract: Reconstruction and analysis of a genome-scale metabolic model for Eriocheir sinensis eyestalks

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Publication details

The article was received on 24 Aug 2015, accepted on 04 Nov 2015 and first published on 06 Nov 2015


Article type: Paper
DOI: 10.1039/C5MB00571J
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Mol. BioSyst., 2016,12, 246-252

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    Reconstruction and analysis of a genome-scale metabolic model for Eriocheir sinensis eyestalks

    B. Wang, Q. Ning, T. Hao, A. Yu and J. Sun, Mol. BioSyst., 2016, 12, 246
    DOI: 10.1039/C5MB00571J

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