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Issue 12, 2016
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Asymmetric axonal edge guidance: a new paradigm for building oriented neuronal networks

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Abstract

We present a novel kind of directional axon guides for brain-on-a-chip applications. Contrarily to previous works, the directionality in our design is created by rerouting axons growing in the unwanted direction back to their original compartment while leaving the other growth direction unaffected. This design yields state-of-the-art levels of directionality without the disadvantages of previously reported technologies.

Graphical abstract: Asymmetric axonal edge guidance: a new paradigm for building oriented neuronal networks

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Article information


Submitted
09 Apr 2016
Accepted
10 May 2016
First published
10 May 2016

Lab Chip, 2016,16, 2188-2191
Article type
Communication

Asymmetric axonal edge guidance: a new paradigm for building oriented neuronal networks

R. Renault, J. Durand, J. Viovy and C. Villard, Lab Chip, 2016, 16, 2188
DOI: 10.1039/C6LC00479B

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