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Issue 20, 2016
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Total synthesis of triazole-linked C-glycosyl flavonoids in alternative solvents and environmental assessment in terms of reaction, workup and purification

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Abstract

An efficient total synthesis of triazole-linked C-glycosyl flavonoids was developed without the use of protective groups in order to promote atom economy, employing alternative solvents, and choosing the least toxic reagents. Aiming to measure the impact of the operation that affects the mass intensity to a greater extent, we envisaged first determining this green metric for the reaction (MIR), the workup (MIW), and the purification (MIP) for each step and then taking advantage of these values to calculate the contributions to the total synthesis.

Graphical abstract: Total synthesis of triazole-linked C-glycosyl flavonoids in alternative solvents and environmental assessment in terms of reaction, workup and purification

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Supplementary files

Article information


Submitted
16 Jun 2016
Accepted
18 Jul 2016
First published
19 Jul 2016

Green Chem., 2016,18, 5558-5568
Article type
Paper

Total synthesis of triazole-linked C-glycosyl flavonoids in alternative solvents and environmental assessment in terms of reaction, workup and purification

F. Pessel, I. Billault and M. Scherrmann, Green Chem., 2016, 18, 5558
DOI: 10.1039/C6GC01647B

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