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Issue 16, 2016
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Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams

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Abstract

The first visible light mediated tin-free cyclisation of α-chloroenamides leading to the synthesis of substituted γ-lactams with excellent stereoselectivity is reported. The protocol employs the single-electron reduction of activated C–Cl bonds, which are typically inert towards reduction.

Graphical abstract: Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams

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Supplementary files

Article information


Submitted
18 Apr 2016
Accepted
24 Jun 2016
First published
13 Jul 2016

This article is Open Access

Green Chem., 2016,18, 4531-4535
Article type
Communication

Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams

E. Fava, M. Nakajima, M. B. Tabak and M. Rueping, Green Chem., 2016, 18, 4531
DOI: 10.1039/C6GC01099G

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