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Issue 2, 2016
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Anti-rheumatoid arthritic effects of Saussurea involucrata on type II collagen-induced arthritis in rats

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Abstract

Saussurea involucrata (SI) has long been used under the herbal name “snow lotus” for treatment of inflammation and pain-related diseases in traditional Chinese medicine. The present study aimed to evaluate the pharmacological effects of SI on collagen II (CII)-induced arthritis in rats. Rats with collagen II (CII)-induced arthritis were orally administered SI (420 mg kg−1) for 40 consecutive days. Histopathological examination indicated that SI alleviates infiltration of inflammatory cells and synovial hyperplasia and slows joint destruction. SI intervention reduced the serum levels of RF, COMP, CRP and anti-CII IgG. Results also showed that SI is a potential therapeutic agent for alleviating the severity of the disease based on the reduced arthritic index. It was concluded that SI can ameliorate inflammation and joint destruction in CIA rats.

Graphical abstract: Anti-rheumatoid arthritic effects of Saussurea involucrata on type II collagen-induced arthritis in rats

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Article information


Submitted
27 May 2015
Accepted
14 Oct 2015
First published
19 Oct 2015

Food Funct., 2016,7, 763-770
Article type
Paper

Anti-rheumatoid arthritic effects of Saussurea involucrata on type II collagen-induced arthritis in rats

M. Xu, Q. Guo, S. Wang, N. Wang, L. Wei and J. Wang, Food Funct., 2016, 7, 763
DOI: 10.1039/C5FO00603A

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