Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Volume 186, 2016
Previous Article Next Article

Membrane-mediated aggregation of anisotropically curved nanoparticles

Author affiliations

Abstract

Using systematic numerical simulations, we study the self-assembly of elongated curved nanoparticles on lipid vesicles. Our simulations are based on molecular dynamics of a coarse-grained implicit-solvent model of self-assembled lipid membranes with a Langevin thermostat. Here we consider only the case wherein the nanoparticle–nanoparticle interaction is repulsive, only the concave surface of the nanoparticle interacts attractively with the lipid head groups and only the outer surface of the vesicle is exposed to the nanoparticles. Upon their adhesion on the vesicle, the curved nanoparticles generate local curvature on the membrane. The resulting nanoparticle-generated membrane curvature leads in turn to nanoparticle self-assembly into two main types of aggregates corresponding to chain aggregates at low adhesion strengths and aster aggregates at high adhesion strength. The chain-like aggregates are due to the fact that at low values of adhesion strength, the nanoparticles prefer to lie parallel to each other. As the adhesion strength is increased, a splay angle between the nanoparticles is induced with a magnitude that increases with increasing adhesion strength. The origin of the splay angles between the nanoparticles is shown to be saddle-like membrane deformations induced by a tilt of the lipids around the nanoparticles. This phenomenon of membrane mediated self-assembly of anisotropically curved nanoparticles is explored for systems with varying nanoparticle number densities, adhesion strength, and nanoparticle intrinsic curvature.

Back to tab navigation

Associated articles

Article information


Submitted
12 Oct 2015
Accepted
03 Nov 2015
First published
03 Nov 2015

Faraday Discuss., 2016,186, 265-275
Article type
Paper
Author version available

Membrane-mediated aggregation of anisotropically curved nanoparticles

A. D. Olinger, E. J. Spangler, P. B. S. Kumar and M. Laradji, Faraday Discuss., 2016, 186, 265
DOI: 10.1039/C5FD00144G

Social activity

Search articles by author

Spotlight

Advertisements