Issue 35, 2016
From the journal:

Dalton Transactions

Investigation of cobalt(iii)-triazole systems as prototypes for hypoxia-activated drug delivery†

Isabela Cristina Aguiar de Souza,‡a   Leticia Villafranca Faro,‡a   Carlos Basilio Pinheiro,b   Daniel Tadeu Gomes Gonzaga,a   Fernando de Carvalho da Silva,a   Vitor Francisco Ferreira,a   Fabio da Silva Miranda,a   Marciela Scarpellinic  and  Mauricio Lanznaster*a  

* Corresponding authors

a Universidade Federal Fluminense, Instituto de Química, Outeiro S. João Batista S/N, Niterói, RJ, Brazil
E-mail: ml@id.uff.br

b Universidade Federal de Minas Gerais, Departamento de Física, Av. Antônio Carlos 6627, Belo Horizonte, MG, Brazil

c Universidade Federal do Rio de Janeiro, Instituto de Química, Av. Athos da Silveira Ramos 149, Rio de Janeiro, RJ, Brazil

Abstract

Three novel cobalt(III)-triazole complexes with structural and redox properties suitable for hypoxia-activated drug delivery were obtained. A major influence of the ancillary ligands (TPA, py2en, py2enMe2) on the electronic properties and reactivity of their complexes was observed. An [O2]-dependent reduction to cobalt(II) by ascorbic acid provided evidence of hypoxic selectivity.

Graphical abstract: Investigation of cobalt(iii)-triazole systems as prototypes for hypoxia-activated drug delivery

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Article information

DOI
https://doi.org/10.1039/C6DT02456D
Article type
Communication
Submitted
21 Jun 2016
Accepted
26 Jul 2016
First published
29 Jul 2016

Dalton Trans., 2016,45, 13671-13674

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Investigation of cobalt(III)-triazole systems as prototypes for hypoxia-activated drug delivery

I. C. A. de Souza, L. V. Faro, C. B. Pinheiro, D. T. G. Gonzaga, F. D. C. da Silva, V. F. Ferreira, F. D. S. Miranda, M. Scarpellini and M. Lanznaster, Dalton Trans., 2016, 45, 13671 DOI: 10.1039/C6DT02456D

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