Jump to main content
Jump to site search

Issue 33, 2016
Previous Article Next Article

Antiproliferative activity of ruthenium(ii) arene complexes with mono- and bidentate pyridine-based ligands

Author affiliations

Abstract

A series of RuII arene complexes of mono- and bidentate N-donor ligands with carboxyl or ester groups and chlorido ancillary ligands were synthesised and structurally characterised. The complexes have a distorted tetrahedral piano-stool geometry. The binding interaction was studied with calf thymus DNA (CT-DNA) by absorption titration, viscosity measurement, thermal melting, circular dichroism, ethidium bromide displacement assay and DNA cleavage of plasmid DNA (pBR322), investigated by gel electrophoresis. The dichlorido complexes bind covalently to DNA in the dark, similar to cisplatin, while the monochlorido complexes bind covalently on irradiation, similar to cisplatin analogues. The compounds are selectively cytotoxic against several tumour cell lines and show specific nonlinear correlation between dose and activity. This phenomenon is closely related to their potential to act preferentially as inhibitors of cell division.

Graphical abstract: Antiproliferative activity of ruthenium(ii) arene complexes with mono- and bidentate pyridine-based ligands

Back to tab navigation

Supplementary files

Article information


Submitted
06 May 2016
Accepted
23 May 2016
First published
24 May 2016

This article is Open Access

Dalton Trans., 2016,45, 13114-13125
Article type
Paper

Antiproliferative activity of ruthenium(II) arene complexes with mono- and bidentate pyridine-based ligands

S. Richter, S. Singh, D. Draca, A. Kate, A. Kumbhar, A. S. Kumbhar, D. Maksimovic-Ivanic, S. Mijatovic, P. Lönnecke and E. Hey-Hawkins, Dalton Trans., 2016, 45, 13114
DOI: 10.1039/C6DT01782G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements