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Issue 34, 2016
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Ruthenium(II) complexes with dppz: from molecular photoswitch to biological applications

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Abstract

The DNA photoswitch [Ru(bpy)2dppz]2+ (bpy = 2,2′-bipyridine, dppz = dipyrido[3,2-a:2′,3′-c]phenazine) has attracted much attention and become a powerful tool for studying the interaction of metal polypyridyl complexes with DNA. A large number of Ru-dppz complexes have been designed for a wide range of uses in many fields. In this perspective, we first introduce the latest results of Ru-dppz complexes that bind with DNA. The mechanisms of the light-switch effect and the structural modifications of Ru-dppz systems are also briefly introduced. We also review the recent advances in biological applications of the Ru-dppz system in DNA binders, cellular imaging, anticancer drugs, protein aggregation detection and chemosensors.

Graphical abstract: Ruthenium(ii) complexes with dppz: from molecular photoswitch to biological applications

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Publication details

The article was received on 27 Apr 2016, accepted on 09 Jul 2016 and first published on 11 Jul 2016


Article type: Perspective
DOI: 10.1039/C6DT01624C
Dalton Trans., 2016,45, 13261-13276

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    Ruthenium(II) complexes with dppz: from molecular photoswitch to biological applications

    G. Li, L. Sun, L. Ji and H. Chao, Dalton Trans., 2016, 45, 13261
    DOI: 10.1039/C6DT01624C

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