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Issue 4, 2016
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A new metal–organic polymeric system capable of stimuli-responsive controlled release of the drug ibuprofen

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Abstract

A series of new zinc compounds has been prepared easily under mild synthetic conditions with the drug ibuprofen incorporated as a ligand to form different coordination polymers. The host materials have a high drug content and exhibit high stability, low cytotoxicity, good biodegradability and high biocompatibility. The ion exchange mechanism involved in the ibuprofen release process and the pH-controlled drug release have been studied.

Graphical abstract: A new metal–organic polymeric system capable of stimuli-responsive controlled release of the drug ibuprofen

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Publication details

The article was received on 14 Oct 2015, accepted on 09 Dec 2015 and first published on 15 Dec 2015


Article type: Paper
DOI: 10.1039/C5DT04031K
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Dalton Trans., 2016,45, 1614-1621
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    A new metal–organic polymeric system capable of stimuli-responsive controlled release of the drug ibuprofen

    A. B. Lago, A. Pino-Cuevas, R. Carballo and E. M. Vázquez-López, Dalton Trans., 2016, 45, 1614
    DOI: 10.1039/C5DT04031K

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