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Issue 18, 2016
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Design and engineering of artificial oxygen-activating metalloenzymes

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Abstract

Many efforts are being made in the design and engineering of metalloenzymes with catalytic properties fulfilling the needs of practical applications. Progress in this field has recently been accelerated by advances in computational, molecular and structural biology. This review article focuses on the recent examples of oxygen-activating metalloenzymes, developed through the strategies of de novo design, miniaturization processes and protein redesign. Considerable progress in these diverse design approaches has produced many metal-containing biocatalysts able to adopt the functions of native enzymes or even novel functions beyond those found in Nature.

Graphical abstract: Design and engineering of artificial oxygen-activating metalloenzymes

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Article information


Submitted
18 Dec 2015
First published
24 Jun 2016

Chem. Soc. Rev., 2016,45, 5020-5054
Article type
Review Article

Design and engineering of artificial oxygen-activating metalloenzymes

F. Nastri, M. Chino, O. Maglio, A. Bhagi-Damodaran, Y. Lu and A. Lombardi, Chem. Soc. Rev., 2016, 45, 5020
DOI: 10.1039/C5CS00923E

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