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Issue 1, 2016
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Natural supramolecular protein assemblies

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Abstract

Supramolecular protein assemblies are an emerging area within the chemical sciences, which combine the topological structures of the field of supramolecular chemistry and the state-of-the-art chemical biology approaches to unravel the formation and function of protein assemblies. Recent chemical and biological studies on natural multimeric protein structures, including fibers, rings, tubes, catenanes, knots, and cages, have shown that the quaternary structures of proteins are a prerequisite for their highly specific biological functions. In this review, we illustrate that a striking structural diversity of protein assemblies is present in nature. Furthermore, we describe structure–function relationship studies for selected classes of protein architectures, and we highlight the techniques that enable the characterisation of supramolecular protein structures.

Graphical abstract: Natural supramolecular protein assemblies

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Publication details

The article was received on 18 Feb 2015 and first published on 26 Oct 2015


Article type: Tutorial Review
DOI: 10.1039/C5CS00157A
Chem. Soc. Rev., 2016,45, 24-39
  • Open access: Creative Commons BY license
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    Natural supramolecular protein assemblies

    B. J. G. E. Pieters, M. B. van Eldijk, R. J. M. Nolte and J. Mecinović, Chem. Soc. Rev., 2016, 45, 24
    DOI: 10.1039/C5CS00157A

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