Issue 1, 2016

Natural supramolecular protein assemblies


Supramolecular protein assemblies are an emerging area within the chemical sciences, which combine the topological structures of the field of supramolecular chemistry and the state-of-the-art chemical biology approaches to unravel the formation and function of protein assemblies. Recent chemical and biological studies on natural multimeric protein structures, including fibers, rings, tubes, catenanes, knots, and cages, have shown that the quaternary structures of proteins are a prerequisite for their highly specific biological functions. In this review, we illustrate that a striking structural diversity of protein assemblies is present in nature. Furthermore, we describe structure–function relationship studies for selected classes of protein architectures, and we highlight the techniques that enable the characterisation of supramolecular protein structures.

Graphical abstract: Natural supramolecular protein assemblies

Article information

Article type
Tutorial Review
18 Feb 2015
First published
26 Oct 2015
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2016,45, 24-39

Natural supramolecular protein assemblies

B. J. G. E. Pieters, M. B. van Eldijk, R. J. M. Nolte and J. Mecinović, Chem. Soc. Rev., 2016, 45, 24 DOI: 10.1039/C5CS00157A

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