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Issue 11, 2016
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Photo-click construction of a targetable and activatable two-photon probe imaging protease in apoptosis

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Abstract

A photo-click reaction was used as an efficient method to construct two-photon fluorescent probes bearing two functional peptides for targeting and for protease cleavage respectively. The activatable two-photon probe constructed by this method was applied to two-photon imaging of caspase-3 both in cellular apoptosis and in tumor tissue.

Graphical abstract: Photo-click construction of a targetable and activatable two-photon probe imaging protease in apoptosis

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Publication details

The article was received on 04 Dec 2015, accepted on 22 Dec 2015 and first published on 22 Dec 2015


Article type: Communication
DOI: 10.1039/C5CC09973K
Chem. Commun., 2016,52, 2342-2345

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    Photo-click construction of a targetable and activatable two-photon probe imaging protease in apoptosis

    M. Zhou, J. Hu, M. Zheng, Q. Song, J. Li and Y. Zhang, Chem. Commun., 2016, 52, 2342
    DOI: 10.1039/C5CC09973K

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