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Issue 11, 2016
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Radical C–H functionalization to construct heterocyclic compounds

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Abstract

Heterocyclic compounds are widely present in natural products, pharmaceuticals and bioactive molecules. Thus, organic and pharmaceutical chemists have been making extensive efforts to construct those heterocyclic frameworks through developing versatile and efficient synthetic strategies. The direct C–H functionalization via the radical pathway has emerged as a promising and dramatic approach towards heterocycles with high atom- and step-economy. Heterocyclic compounds such as coumarins, furans, benzofurans, xanthones, benzothiazoles, indoles, indolines, oxindoles, quinolines, isoquinolines, quinoxaline, and phenanthridines have been successfully synthesized by C–H functionalization through the radical pathway. In this review, recent advances on radical C–H functionalization to construct heterocyclic compounds are highlighted with discussions.

Graphical abstract: Radical C–H functionalization to construct heterocyclic compounds

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Publication details

The article was received on 26 Oct 2015, accepted on 17 Dec 2015 and first published on 17 Dec 2015


Article type: Feature Article
DOI: 10.1039/C5CC08872K
Chem. Commun., 2016,52, 2220-2236

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    Radical C–H functionalization to construct heterocyclic compounds

    J. Yu and C. Pan, Chem. Commun., 2016, 52, 2220
    DOI: 10.1039/C5CC08872K

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