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Issue 7, 2016
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Cobalt(III) catalyzed C-8 selective C–H and C–O coupling of quinoline N-oxide with internal alkynes via C–H activation and oxygen atom transfer

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Abstract

An efficient, scalable, atom-economical, regio-selective air stable Cp*Co(III) catalyzed C–H and C–O coupling via a C–H activation/oxygen atom transfer reaction of quinoline N-oxide and an internal alkyne is reported. Such a catalytic transformation is witnessed for the first time with a cobalt catalyst and using N-oxide as a traceless directing group, in contrast to the existing literature. The developed synthetic methodology is straightforward and possesses various functional group tolerances, including heterocycles.

Graphical abstract: Cobalt(iii) catalyzed C-8 selective C–H and C–O coupling of quinoline N-oxide with internal alkynes via C–H activation and oxygen atom transfer

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Publication details

The article was received on 22 Oct 2015, accepted on 23 Nov 2015 and first published on 23 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC08736H
Chem. Commun., 2016,52, 1338-1341
  • Open access: Creative Commons BY-NC license
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    Cobalt(III) catalyzed C-8 selective C–H and C–O coupling of quinoline N-oxide with internal alkynes via C–H activation and oxygen atom transfer

    N. Barsu, M. Sen, J. R. Premkumar and B. Sundararaju, Chem. Commun., 2016, 52, 1338
    DOI: 10.1039/C5CC08736H

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