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Issue 96, 2016
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Remote meta C–H bond functionalization of 2-phenethylsulphonic acid and 3-phenylpropanoic acid derivatives

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Abstract

This discovery illustrates selective meta C–H bond activation from multiple non-equivalent C–H bonds present in medicinally relevant arylethanesulfonic acid and the 2-arylpropanoic acid moiety using weakly coordinating nitrile as a directing group. Transformation of the meta olefinated compounds to important organic molecules has been demonstrated. Efforts were made to obtain mechanistic detail of the meta C–H bond functionalization reaction.

Graphical abstract: Remote meta C–H bond functionalization of 2-phenethylsulphonic acid and 3-phenylpropanoic acid derivatives

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Publication details

The article was received on 14 Oct 2016, accepted on 07 Nov 2016 and first published on 07 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC08302A
Chem. Commun., 2016,52, 13916-13919

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    Remote meta C–H bond functionalization of 2-phenethylsulphonic acid and 3-phenylpropanoic acid derivatives

    A. Modak, A. Mondal, R. Watile, S. Mukherjee and D. Maiti, Chem. Commun., 2016, 52, 13916
    DOI: 10.1039/C6CC08302A

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