Palladium catalyzed selective distal C–H olefination of biaryl systems†
Palladium catalyzed selective distal C–H activation with nitrile based templates has been of significant research interest in recent times. In this report, we disclose the distal C–H olefination of biphenyl systems with high regio- and stereo-selectivity and useful synthetic yields. The utility of this method has been demonstrated through its wide olefin scope, its operation at the gram scale and the easy removal/recovery of the directing group.
- This article is part of the themed collection: Site-selective molecular transformations