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Issue 88, 2016
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Two-dimensional metal–organic framework nanosheets as a matrix for laser desorption/ionization of small molecules and monitoring enzymatic reactions at high salt concentrations

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Abstract

Stable 2-D metal–organic framework nanosheets were utilized as a superior clean-background matrix for MALDI-TOF MS analysis of small biomolecules and pollutants in both positive and negative ion modes. The matrix could unusually afford up to 1000 mM of the salt concentrations in the monitoring of the enzymatic hydrolysis of neurotransmitter acetylcholine.

Graphical abstract: Two-dimensional metal–organic framework nanosheets as a matrix for laser desorption/ionization of small molecules and monitoring enzymatic reactions at high salt concentrations

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Supplementary files

Article information


Submitted
09 Sep 2016
Accepted
07 Oct 2016
First published
07 Oct 2016

Chem. Commun., 2016,52, 12984-12987
Article type
Communication

Two-dimensional metal–organic framework nanosheets as a matrix for laser desorption/ionization of small molecules and monitoring enzymatic reactions at high salt concentrations

H. Liu, Y. Chang, T. Fan and Z. Gu, Chem. Commun., 2016, 52, 12984
DOI: 10.1039/C6CC07371A

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