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Issue 75, 2016
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Multivalent effect of glycopolypeptide based nanoparticles for galectin binding

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Abstract

Synthetic glycopolypeptides are versatile glycopolymers used to conceive bioinspired nanoassemblies. In this work, novel amphiphilic glycopolypeptides were designed to incorporate lactose or galactan in order to prepare polymeric nanoassemblies with sizes below 50 nm. The bioactivity of the two different outer surface sugar units was evaluated by defining glycan relative binding affinities to human galectins 1 and 3. A specific multivalent effect was found only for polymeric nanoparticles displaying galactan with a significant increase of the binding activity as compared to free glycan in solution. Such synthetic designs present great potential as therapeutic tools to address galectin related pathologies.

Graphical abstract: Multivalent effect of glycopolypeptide based nanoparticles for galectin binding

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Supplementary files

Article information


Submitted
04 Aug 2016
Accepted
18 Aug 2016
First published
18 Aug 2016

Chem. Commun., 2016,52, 11251-11254
Article type
Communication

Multivalent effect of glycopolypeptide based nanoparticles for galectin binding

C. Bonduelle, H. Oliveira, C. Gauche, J. Huang, A. Heise and S. Lecommandoux, Chem. Commun., 2016, 52, 11251
DOI: 10.1039/C6CC06437J

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