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Issue 80, 2016
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Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

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Abstract

In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition properties against some carbonic anhydrases (CAs), recognized as important drug targets, and the characterization of the binding mode of these molecules to the CA active site. Our data provide the first experimental evidence that benzoxaboroles can be efficiently used as CA inhibitors.

Graphical abstract: Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

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Publication details

The article was received on 03 Aug 2016, accepted on 08 Sep 2016 and first published on 08 Sep 2016


Article type: Communication
DOI: 10.1039/C6CC06399C
Chem. Commun., 2016,52, 11983-11986

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    Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

    V. Alterio, R. Cadoni, D. Esposito, D. Vullo, A. D. Fiore, S. M. Monti, A. Caporale, M. Ruvo, M. Sechi, P. Dumy, C. T. Supuran, G. D. Simone and J. Winum, Chem. Commun., 2016, 52, 11983
    DOI: 10.1039/C6CC06399C

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