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Issue 57, 2016
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Direct amidation of unprotected amino acids using B(OCH2CF3)3

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Abstract

A commercially available borate ester, B(OCH2CF3)3, can be used to achieve protecting-group free direct amidation of α-amino acids with a range of amines in cyclopentyl methyl ether. The method can be applied to the synthesis of medicinally relevant compounds, and can be scaled up to obtain gram quantities of products.

Graphical abstract: Direct amidation of unprotected amino acids using B(OCH2CF3)3

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Supplementary files

Article information


Submitted
29 Jan 2016
Accepted
22 Jun 2016
First published
22 Jun 2016

This article is Open Access

Chem. Commun., 2016,52, 8846-8849
Article type
Communication
Author version available

Direct amidation of unprotected amino acids using B(OCH2CF3)3

R. M. Lanigan, V. Karaluka, M. T. Sabatini, P. Starkov, M. Badland, L. Boulton and T. D. Sheppard, Chem. Commun., 2016, 52, 8846
DOI: 10.1039/C6CC05147B

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