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Issue 75, 2016
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Nanoparticle “switch-on” by tetrazine triggering

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This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels–Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent doxorubicin and its triggered release, allowing controlled cell death in response to a small-molecule chemical trigger.

Graphical abstract: Nanoparticle “switch-on” by tetrazine triggering

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The article was received on 19 Jun 2016, accepted on 19 Aug 2016 and first published on 19 Aug 2016

Article type: Communication
DOI: 10.1039/C6CC05118A
Chem. Commun., 2016,52, 11223-11226
  • Open access: Creative Commons BY license
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    Nanoparticle “switch-on” by tetrazine triggering

    K. Neumann, S. Jain, J. Geng and M. Bradley, Chem. Commun., 2016, 52, 11223
    DOI: 10.1039/C6CC05118A

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