A traceless photocleavable linker for the automated glycan assembly of carbohydrates with free reducing ends

M. Wilsdorf; D. Schmidt; M. P. Bartetzko; P. Dallabernardina; F. Schuhmacher; P. H. Seeberger; F. Pfrengle

doi:10.1039/C6CC04954K

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A traceless photocleavable linker for the automated glycan assembly of carbohydrates with free reducing ends†

M. Wilsdorf,^a D. Schmidt,^ab M. P. Bartetzko,^ab P. Dallabernardina,^ab F. Schuhmacher,^ab P. H. Seeberger^ab and F. Pfrengle*^ab

Author affiliations

* Corresponding authors

^a Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
E-mail: Fabian.Pfrengle@mpikg.mpg.de

^b Freie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany

Abstract

We report a traceless photocleavable linker for the automated glycan assembly of carbohydrates with free reducing ends. The reductive-labile functionality in the linker tolerates all commonly used reagents and protocols for automated glycan assembly, as demonstrated with the successful preparation of nine plant cell wall-related oligosaccharides, and is cleaved by hydrogenolysis.

Download options Please wait...

Supplementary files

Supplementary information PDF (4731K)

Article information

DOI: https://doi.org/10.1039/C6CC04954K
Article type: Communication
Submitted: 14 Jun 2016
Accepted: 15 Jul 2016
First published: 15 Jul 2016
This article is Open Access

Download Citation

Chem. Commun., 2016,52, 10187-10189

Permissions

Request permissions

A traceless photocleavable linker for the automated glycan assembly of carbohydrates with free reducing ends

M. Wilsdorf, D. Schmidt, M. P. Bartetzko, P. Dallabernardina, F. Schuhmacher, P. H. Seeberger and F. Pfrengle, Chem. Commun., 2016, 52, 10187 DOI: 10.1039/C6CC04954K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

A traceless photocleavable linker for the automated glycan assembly of carbohydrates with free reducing ends†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A traceless photocleavable linker for the automated glycan assembly of carbohydrates with free reducing ends

Social activity

Search articles by author

Spotlight

Advertisements