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Issue 66, 2016
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Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents

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Abstract

Post-translational methylation is a chemically simple modification, but regulates the function of hundreds of proteins in profound ways. This Feature Article will report on the basic aspects of protein methylation, and will offer a personal perspective on our recent efforts at making supramolecular hosts that can bind and discriminate among post-translationally methylated partners. The article highlights several general lessons drawn from these efforts and related work by other groups. It also describes some ways in which supramolecular approaches are inherently well suited to provide tools that drive new research in the life sciences.

Graphical abstract: Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents

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Article information


Submitted
07 Jun 2016
Accepted
28 Jun 2016
First published
29 Jun 2016

This article is Open Access

Chem. Commun., 2016,52, 10093-10108
Article type
Feature Article

Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents

F. Hof, Chem. Commun., 2016, 52, 10093
DOI: 10.1039/C6CC04771H

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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