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Issue 65, 2016
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Palladium(II)-catalyzed C–C and C–O bond formation for the synthesis of C1-benzoyl isoquinolines from isoquinoline N-oxides and nitroalkenes

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Abstract

C1-Benzoyl isoquinolines can be generated via a palladium(II)-catalyzed C–C and C–O coupling of isoquinoline N-oxides with aromatic nitroalkenes. The reaction proceeds through remote C–H bond activation and subsequent intramolecular oxygen atom transfer (OAT). In this reaction, the N–O bond was designed as a directing group in the C–H bond activation as well as the source of an oxygen atom.

Graphical abstract: Palladium(ii)-catalyzed C–C and C–O bond formation for the synthesis of C1-benzoyl isoquinolines from isoquinoline N-oxides and nitroalkenes

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Publication details

The article was received on 27 Apr 2016, accepted on 08 Jul 2016 and first published on 14 Jul 2016


Article type: Communication
DOI: 10.1039/C6CC03530B
Chem. Commun., 2016,52, 10028-10031

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    Palladium(II)-catalyzed C–C and C–O bond formation for the synthesis of C1-benzoyl isoquinolines from isoquinoline N-oxides and nitroalkenes

    J. Li, W. Li, Y. Wang, Q. Ren, H. Wang and Y. Pan, Chem. Commun., 2016, 52, 10028
    DOI: 10.1039/C6CC03530B

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