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Issue 60, 2016
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Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules

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Abstract

Bacteria utilize nucleotide-based second messengers to regulate a myriad of physiological processes. Cyclic dinucleotides have emerged as central regulators of bacterial physiology, controlling processes ranging from cell wall homeostasis to virulence production, and so far over thousands of manuscripts have provided biological insights into c-di-NMP signaling. The development of small molecule inhibitors of c-di-NMP signaling has significantly lagged behind. Recent developments in assays that allow for high-throughput screening of inhibitors suggest that the time is right for a concerted effort to identify inhibitors of these fascinating second messengers. Herein, we review c-di-NMP signaling and small molecules that have been developed to inhibit cyclic dinucleotide-related enzymes.

Graphical abstract: Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules

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Publication details

The article was received on 25 Apr 2016, accepted on 07 Jun 2016 and first published on 08 Jun 2016


Article type: Feature Article
DOI: 10.1039/C6CC03439J
Chem. Commun., 2016,52, 9327-9342
  • Open access: Creative Commons BY license
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    Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules

    C. Opoku-Temeng, J. Zhou, Y. Zheng, J. Su and H. O. Sintim, Chem. Commun., 2016, 52, 9327
    DOI: 10.1039/C6CC03439J

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