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Issue 49, 2016
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Screening of a virtual mirror-image library of natural products

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Abstract

We established a facile access to an unexplored mirror-image library of chiral natural product derivatives using D-protein technology. In this process, two chemical syntheses of mirror-image substances including a target protein and hit compound(s) allow the lead discovery from a virtual mirror-image library without the synthesis of numerous mirror-image compounds.

Graphical abstract: Screening of a virtual mirror-image library of natural products

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Publication details

The article was received on 14 Apr 2016, accepted on 11 May 2016 and first published on 11 May 2016


Article type: Communication
DOI: 10.1039/C6CC03114E
Chem. Commun., 2016,52, 7653-7656
  • Open access: Creative Commons BY license
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    Screening of a virtual mirror-image library of natural products

    T. Noguchi, S. Oishi, K. Honda, Y. Kondoh, T. Saito, H. Ohno, H. Osada and N. Fujii, Chem. Commun., 2016, 52, 7653
    DOI: 10.1039/C6CC03114E

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