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Issue 55, 2016
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A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing

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Abstract

A new DNA building block (dTetU) bearing a tetrazole and allyloxy group at N-phenyl ring linked through an aminopropynyl linker to the 5-position of 2′-deoxyuridine was synthesized. The modified DNA can be lit up via a photoinduced intramolecular tetrazole–alkene cycloaddition reaction, but quenched when the fully-matched double strand is formed. This conspicuous difference in fluorescence could open a door for DNA single nucleotide polymorphism (SNP) typing.

Graphical abstract: A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing

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Publication details

The article was received on 13 Apr 2016, accepted on 10 Jun 2016 and first published on 10 Jun 2016


Article type: Communication
DOI: 10.1039/C6CC03098J
Chem. Commun., 2016,52, 8545-8548

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    A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing

    Z. He, Y. Chen, Y. Wang, J. Wang, J. Mo, B. Fu, Z. Wang, Y. Du and X. Zhou, Chem. Commun., 2016, 52, 8545
    DOI: 10.1039/C6CC03098J

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