Jump to main content
Jump to site search

Issue 62, 2016
Previous Article Next Article

Simple magnesium catalyst mediated γ-butyrolactams in desymmetrization of meso-aziridines

Author affiliations

Abstract

The first α-sp2-carbon of carbonyl compounds attacked catalytic desymmetrization reaction of aziridines is disclosed. A simple in situ generated magnesium catalyst from 3,3′-bromine-8H-BINOL and dibutylmagnesium was employed. It is interesting that the bromine atom on the chiral ligand plays a key role in introducing a high level of enantioselectivities and high reaction efficiency. Both enantiomers of the ring-opening product could be smoothly obtained by using (R)- and (S)-L7.

Graphical abstract: Simple magnesium catalyst mediated γ-butyrolactams in desymmetrization of meso-aziridines

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Apr 2016, accepted on 14 Jun 2016 and first published on 14 Jun 2016


Article type: Communication
DOI: 10.1039/C6CC02877B
Chem. Commun., 2016,52, 9640-9643

  •   Request permissions

    Simple magnesium catalyst mediated γ-butyrolactams in desymmetrization of meso-aziridines

    D. Li, Y. Wang, L. Wang, J. Wang, P. Wang, K. Wang, L. Lin, D. Liu, X. Jiang and D. Yang, Chem. Commun., 2016, 52, 9640
    DOI: 10.1039/C6CC02877B

Search articles by author

Spotlight

Advertisements