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Issue 47, 2016
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Harnessing NMR relaxation interference effects to characterise supramolecular assemblies

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Abstract

Solution-state NMR spectroscopy remains the primary method for characterising synthetic supramolecular assemblies. Yet, in their NMR spectra, relaxation interference effects can significantly alter peak intensities hindering interpretation. Here, we present a simple experiment for synthetic chemists to analyse this effect, allowing interpretation of these distorted spectra and validation of spectral assignments. We apply this experiment to synthetic porphyrin oligomers with molecular weights approaching those of protein domains (10 kDa). Our experiment provides a simple means to gain additional structural and dynamical information that will become increasingly useful as chemists create larger molecular architectures.

Graphical abstract: Harnessing NMR relaxation interference effects to characterise supramolecular assemblies

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Supplementary files

Article information


Submitted
24 Mar 2016
Accepted
15 Apr 2016
First published
15 Apr 2016

Chem. Commun., 2016,52, 7450-7453
Article type
Communication
Author version available

Harnessing NMR relaxation interference effects to characterise supramolecular assemblies

G. Karunanithy, A. Cnossen, H. Müller, M. D. Peeks, N. H. Rees, T. D. W. Claridge, H. L. Anderson and A. J. Baldwin, Chem. Commun., 2016, 52, 7450
DOI: 10.1039/C6CC02544G

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