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Issue 34, 2016
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Rhodium-catalyzed chemo- and regioselective decarboxylative addition of β-ketoacids to alkynes

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Abstract

A highly efficient rhodium-catalyzed chemo- and regioselective addition of β-ketoacids to alkynes is reported. Applying a Rh(I)/(S,S)-DIOP catalyst system, γ,δ-unsaturated ketones were prepared with exclusively branched selectivity under mild conditions. This demonstrates that readily available alkynes can be an alternative entry to allyl electrophiles in transition-metal catalyzed allylic alkylation reactions.

Graphical abstract: Rhodium-catalyzed chemo- and regioselective decarboxylative addition of β-ketoacids to alkynes

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Publication details

The article was received on 16 Feb 2016, accepted on 24 Mar 2016 and first published on 29 Mar 2016


Article type: Communication
DOI: 10.1039/C6CC02272C
Chem. Commun., 2016,52, 5840-5843

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    Rhodium-catalyzed chemo- and regioselective decarboxylative addition of β-ketoacids to alkynes

    C. Li, C. P. Grugel and B. Breit, Chem. Commun., 2016, 52, 5840
    DOI: 10.1039/C6CC02272C

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