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Issue 42, 2016
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Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

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Abstract

We here report on the design and synthesis of tailor-made furan-modified peptide nucleic acid (PNA) probes for covalent targeting of single stranded DNA through a crosslinking strategy. After introducing furan-containing building blocks into a PNA sequence, hybridization and furan-oxidation based crosslinking to DNA is investigated. The structure of the crosslinked products is characterized and preliminary investigations concerning the application of these systems to double stranded DNA are shown.

Graphical abstract: Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

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Article information


Submitted
08 Mar 2016
Accepted
22 Apr 2016
First published
27 Apr 2016

Chem. Commun., 2016,52, 6930-6933
Article type
Communication
Author version available

Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

A. Manicardi, E. Gyssels, R. Corradini and A. Madder, Chem. Commun., 2016, 52, 6930
DOI: 10.1039/C6CC02062C

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