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Issue 48, 2016
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Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds

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Abstract

A unique organocatalytic system for Mukaiyama-type aldol reactions based on the cooperative action of nitro compounds and thioureas has been identified. This system is compatible with a wide range of substrates and does not require low temperatures, inert atmospheres, or an aqueous workup. A catalytic mechanism based on nitro group-mediated silyl cation transfer has been proposed.

Graphical abstract: Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds

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Article information


Submitted
05 Mar 2016
Accepted
16 May 2016
First published
16 May 2016

Chem. Commun., 2016,52, 7576-7579
Article type
Communication

Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds

K. V. Bukhryakov, V. G. Desyatkin and V. O. Rodionov, Chem. Commun., 2016, 52, 7576
DOI: 10.1039/C6CC01984F

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