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Issue 47, 2016
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β-Peptide bundles: Design. Build. Analyze. Biosynthesize.

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Peptides containing β-amino acids are unique non-natural polymers known to assemble into protein-like tertiary and quaternary structures. When composed solely of β-amino acids, the structures formed, defined assemblies of 14-helices called β-peptide bundles, fold cooperatively in water solvent into unique and discrete quaternary assemblies that are highly thermostable, bind complex substrates and metal ion cofactors, and, in certain cases, catalyze chemical reactions. In this Perspective, we recount the design and elaboration of β-peptide bundles and provide an outlook on recent, unexpected discoveries that could influence research on β-peptides and β-peptide bundles (and β-amino acid-containing proteins) for decades to come.

Graphical abstract: β-Peptide bundles: Design. Build. Analyze. Biosynthesize.

  • This article is part of the themed collection: Foldamers
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Article information

19 Feb 2016
21 Apr 2016
First published
05 May 2016

Chem. Commun., 2016,52, 7420-7432
Article type
Feature Article
Author version available

β-Peptide bundles: Design. Build. Analyze. Biosynthesize.

P. S. P. Wang and A. Schepartz, Chem. Commun., 2016, 52, 7420
DOI: 10.1039/C6CC01546H

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