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Issue 32, 2016
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Single molecule study of initial structural features on the amyloidosis process

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Abstract

We employed an α-hemolysin (α-HL) nanopore as a single-molecule tool to investigate the effects of initial structure on the amyloidosis process. The differences in the initial structure of two β-amyloid (Aβ) peptides (Aβ25–35 and Aβ35–25) could be distinguished in real-time due to their characteristic blockades. More importantly, the distinct aggregate dynamics for these two kinds of Aβ fragments can be readily analyzed by monitoring the blockade frequency over time.

Graphical abstract: Single molecule study of initial structural features on the amyloidosis process

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Publication details

The article was received on 11 Feb 2016, accepted on 17 Mar 2016 and first published on 17 Mar 2016


Article type: Communication
DOI: 10.1039/C6CC01292B
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Chem. Commun., 2016,52, 5542-5545

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    Single molecule study of initial structural features on the amyloidosis process

    Y. Hu, Y. Ying, Z. Gu, C. Cao, B. Yan, H. Wang and Y. Long, Chem. Commun., 2016, 52, 5542
    DOI: 10.1039/C6CC01292B

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