Issue 22, 2016

Chiral-at-metal iridium complex for efficient enantioselective transfer hydrogenation of ketones

Abstract

A bis-cyclometalated iridium(III) complex with metal-centered chirality catalyzes the enantioselective transfer hydrogenation of ketones with high enantioselectivities at low catalyst loadings down to 0.002 mol%. Importantly, the rate of catalysis and enantioselectivity are markedly improved in the presence of a pyrazole co-ligand. The reaction is proposed to proceed via an iridium-hydride intermediate exploiting metal–ligand cooperativity (bifunctional catalysis).

Graphical abstract: Chiral-at-metal iridium complex for efficient enantioselective transfer hydrogenation of ketones

Supplementary files

Article information

Article type
Communication
Submitted
31 Jan 2016
Accepted
22 Feb 2016
First published
22 Feb 2016
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2016,52, 4207-4210

Chiral-at-metal iridium complex for efficient enantioselective transfer hydrogenation of ketones

C. Tian, L. Gong and E. Meggers, Chem. Commun., 2016, 52, 4207 DOI: 10.1039/C6CC00972G

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