Issue 27, 2016

Dynamic foldamer chemistry


Foldamers can be made more than pieces of static, conformationally uniform molecular architecture by designing into their structure the conformational dynamism characteristic of functional molecular machines. We show that these dynamic foldamers display biomimetic properties reminiscent of allosteric proteins and receptor molecules. They can translate chemical signals into conformational changes, and hence into chemical outputs such as control of reactivity and selectivity. Future developments could see dynamic foldamers operating in the membrane phase providing artificial mechanisms for communication and control that integrate synthetic chemistry into synthetic biology.

Graphical abstract: Dynamic foldamer chemistry

  • This article is part of the themed collection: Foldamers

Article information

Article type
Feature Article
26 Jan 2016
01 Mar 2016
First published
02 Mar 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 4852-4863

Author version available

Dynamic foldamer chemistry

B. A. F. Le Bailly and J. Clayden, Chem. Commun., 2016, 52, 4852 DOI: 10.1039/C6CC00788K

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