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Issue 58, 2016
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Chemical fragment arrays for rapid druggability assessment

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Abstract

Incorporation of early druggability assessment in the drug discovery process provides a means to prioritize target proteins for high-throughput screening. We present chemical fragment arrays as a method that is capable of determining the druggability of a given target with low protein and compound consumption, enabling rapid decision making during early phases of drug discovery.

Graphical abstract: Chemical fragment arrays for rapid druggability assessment

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Publication details

The article was received on 21 Dec 2015, accepted on 10 Feb 2016 and first published on 10 Feb 2016


Article type: Communication
DOI: 10.1039/C5CC10457B
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Chem. Commun., 2016,52, 9067-9070
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    Chemical fragment arrays for rapid druggability assessment

    J. Aretz, Y. Kondoh, K. Honda, U. R. Anumala, M. Nazaré, N. Watanabe, H. Osada and C. Rademacher, Chem. Commun., 2016, 52, 9067
    DOI: 10.1039/C5CC10457B

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