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Issue 24, 2016
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Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

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Abstract

Photoactivatable CO releasing protein crystals were developed by immobilization of Mn carbonyl complexes in polyhedral crystals, which are spontaneously formed in insect cells. The photoactivatable CO release from the engineered protein crystals activates nuclear factor kappa B (NF-κB) upon stimulation by visible light irradiation with suppression of cytotoxicity of the Mn complex.

Graphical abstract: Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

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Supplementary files

Article information


Submitted
20 Dec 2015
Accepted
29 Feb 2016
First published
01 Mar 2016

This article is Open Access

Chem. Commun., 2016,52, 4545-4548
Article type
Communication

Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

H. Tabe, T. Shimoi, M. Boudes, S. Abe, F. Coulibaly, S. Kitagawa, H. Mori and T. Ueno, Chem. Commun., 2016, 52, 4545
DOI: 10.1039/C5CC10440H

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