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Issue 21, 2016
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Light-up fluorophore–DNA aptamer pair for label-free turn-on aptamer sensors

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Abstract

We developed a light-up fluorophore–DNA aptamer pair for label-free aptamer sensors that fluoresce upon binding to the analyte. A 42mer DNA aptamer binding to the environment-sensitive fluorophore, dapoxyl, which increased the fluorescence by more than 700-fold upon binding, was successfully used to construct aptamer sensors by fusion with analyte-binding DNA aptamers.

Graphical abstract: Light-up fluorophore–DNA aptamer pair for label-free turn-on aptamer sensors

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Article information


Submitted
23 Oct 2015
Accepted
12 Feb 2016
First published
12 Feb 2016

Chem. Commun., 2016,52, 4041-4044
Article type
Communication

Light-up fluorophore–DNA aptamer pair for label-free turn-on aptamer sensors

T. Kato, I. Shimada, R. Kimura and M. Hyuga, Chem. Commun., 2016, 52, 4041
DOI: 10.1039/C5CC08816J

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