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Issue 5, 2016
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Click and release: fluoride cleavable linker for mild bioorthogonal separation

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Abstract

Herein, we present a water dispersable, magnetic nanoparticle supported “click and release” system. The cleavable linker has been synthesized by using a strain-promoted copper-free “click” reagent to establish the specific link and a fluoride cleavable silane moiety for mild cleavage. Small organic molecules, azide-bearing dyes and functionalized enzymes have been bound to the magnetic particle and released in a bioorthogonal way.

Graphical abstract: Click and release: fluoride cleavable linker for mild bioorthogonal separation

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Supplementary files

Article information


Submitted
14 Sep 2015
Accepted
16 Nov 2015
First published
16 Nov 2015

Chem. Commun., 2016,52, 938-941
Article type
Communication
Author version available

Click and release: fluoride cleavable linker for mild bioorthogonal separation

E. M. Schneider, M. Zeltner, V. Zlateski, R. N. Grass and W. J. Stark, Chem. Commun., 2016, 52, 938
DOI: 10.1039/C5CC07692G

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