Issue 5, 2016

Click and release: fluoride cleavable linker for mild bioorthogonal separation

Abstract

Herein, we present a water dispersable, magnetic nanoparticle supported “click and release” system. The cleavable linker has been synthesized by using a strain-promoted copper-free “click” reagent to establish the specific link and a fluoride cleavable silane moiety for mild cleavage. Small organic molecules, azide-bearing dyes and functionalized enzymes have been bound to the magnetic particle and released in a bioorthogonal way.

Graphical abstract: Click and release: fluoride cleavable linker for mild bioorthogonal separation

Supplementary files

Article information

Article type
Communication
Submitted
14 Sep 2015
Accepted
16 Nov 2015
First published
16 Nov 2015

Chem. Commun., 2016,52, 938-941

Author version available

Click and release: fluoride cleavable linker for mild bioorthogonal separation

E. M. Schneider, M. Zeltner, V. Zlateski, R. N. Grass and W. J. Stark, Chem. Commun., 2016, 52, 938 DOI: 10.1039/C5CC07692G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements