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Issue 8, 2016
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Bio-inspired cisplatin nanocarriers for osteosarcoma treatment

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Abstract

In this study, cisplatin (cis-diaminedichloroplatinum, CDDP) nanocarriers with phosphorylcholine surface tailoring were developed to enhance the anti-tumor potential of CDDP for the treatment of osteosarcoma. Poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(methacrylic acid) (PMPC-b-PMAA) was synthesized for the preparation of CDDP/PMPC-b-PMAA micelles. The synthesis, self-assembly, and in vitro drug release were well characterized. In vitro cytotoxicity showed that CDDP/PMPC-b-PMAA micelles can strongly inhibit the proliferation of Saos-2 cells. In vivo experiments indicated that CDDP/PMPC-b-PMAA micelles showed prolonged circulation time, reduced renal accumulation, and enhanced tumor accumulation compared to free CDDP. Overall, the CDDP/PMPC-b-PMAA micelles exhibited optimal anti-tumor activity with minimal side effects in the treatment of osteosarcoma.

Graphical abstract: Bio-inspired cisplatin nanocarriers for osteosarcoma treatment

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Article information


Submitted
12 May 2016
Accepted
30 May 2016
First published
17 Jun 2016

Biomater. Sci., 2016,4, 1212-1218
Article type
Paper

Bio-inspired cisplatin nanocarriers for osteosarcoma treatment

H. Zhou, G. Wang, Y. Lu and Z. Pan, Biomater. Sci., 2016, 4, 1212
DOI: 10.1039/C6BM00331A

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