Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 6, 2016
Previous Article Next Article

Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability

Author affiliations

Abstract

Here, we evaluate how cationic gallic acid-triethylene glycol (GATG) dendrimers interact with bacteria and their potential to develop new antimicrobials. We demonstrate that GATG dendrimers functionalised with primary amines in their periphery can induce the formation of clusters in Vibrio harveyi, an opportunistic marine pathogen, in a generation dependent manner. Moreover, these cationic GATG dendrimers demonstrate an improved ability to induce cluster formation when compared to poly(N-[3-(dimethylamino)propyl]methacrylamide) [p(DMAPMAm)], a cationic linear polymer previously shown to cluster bacteria. Viability of the bacteria within the formed clusters and evaluation of quorum sensing controlled phenotypes (i.e. light production in V. harveyi) suggest that GATG dendrimers may be activating microbial responses by maintaining a high concentration of quorum sensing signals inside the clusters while increasing permeability of the microbial outer membranes. Thus, the reported GATG dendrimers constitute a valuable platform for the development of novel antimicrobial materials that can target microbial viability and/or virulence.

Graphical abstract: Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability

Back to tab navigation

Supplementary files

Article information


Submitted
03 Feb 2016
Accepted
08 Apr 2016
First published
29 Apr 2016

Biomater. Sci., 2016,4, 998-1006
Article type
Paper

Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability

E. Leire, S. P. Amaral, I. Louzao, K. Winzer, C. Alexander, E. Fernandez-Megia and F. Fernandez-Trillo, Biomater. Sci., 2016, 4, 998
DOI: 10.1039/C6BM00079G

Social activity

Search articles by author

Spotlight

Advertisements