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Issue 48, 2016
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Trends in photonic lab-on-chip interferometric biosensors for point-of-care diagnostics

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Abstract

Portable point-of care (POC) devices for in vitro diagnostics will be a milestone for the achievement of universal healthcare and environmental protection. The main goal is to reach a rapid, user-friendly and highly sensitive portable tool which can provide immediate results in any place at any time while having a competitive cost. Integrated optical (IO) waveguide based-biosensors are the most suitable candidates to achieve this ambitious objective. They are able to operate in real samples (such as blood, urine, wastewater…) affording relevant sensitivities even under a label-free scheme. In addition, arrays of IO sensors for multiplexed analysis can be integrated in lab-on-chip (LOC) platforms, providing a truly cost-effective fabrication and miniaturization. Among the different IO biosensors, interferometric ones have demonstrated the highest sensitivity for label-free detection ever reported. Although the first interferometric biosensors were developed in the early nineties, they focused mainly on preliminary proof-of-concept studies; only recently the resilient potential of interferometric biosensors as highly advanced POC devices has firmly emerged. This review provides an overview of the state-of-the art in photonic interferometric biosensors, their main biofunctionalisation routes and their integration in LOC platforms, while maintaining a special focus on the real analytical applications achieved so far.

Graphical abstract: Trends in photonic lab-on-chip interferometric biosensors for point-of-care diagnostics

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Publication details

The article was received on 30 Oct 2016, accepted on 08 Nov 2016 and first published on 09 Nov 2016


Article type: Minireview
DOI: 10.1039/C6AY02972H
Anal. Methods, 2016,8, 8380-8394

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    Trends in photonic lab-on-chip interferometric biosensors for point-of-care diagnostics

    A. B. González-Guerrero, J. Maldonado, S. Herranz and L. M. Lechuga, Anal. Methods, 2016, 8, 8380
    DOI: 10.1039/C6AY02972H

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