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Issue 26, 2016
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A label-free electrochemiluminescence aptasensor for carcinoembryonic antigen detection based on electrodeposited ZnS–CdS on MoS2 decorated electrode

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Abstract

In this work, a novel, simple and label-free electrochemiluminescence (ECL) strategy was designed for a sensitive carcinoembryonic antigen (CEA) assay on the basis of ZnS–CdS nanoparticle (NP)-decorated molybdenum disulfide (MoS2) nanocomposites. Layered-MoS2 nanocomposites with a large surface area were prepared with a facile hydrothermal method and used as an electrode matrix for subsequent ZnS–CdS NP electrodeposition. The ZnS–CdS NP decorated MoS2 electrode shows a higher ECL intensity than an electrode with only ZnS–CdS electrodeposition. For the fabrication of the aptasensor, chitosan was coated on a ZnS–CdS/MoS2/glass carbon electrode for CEA aptamer immobilization through a covalent coupling method. The ECL aptasensor for CEA detection exhibits a linear range from 0.05 to 20 ng mL−1 (R = 0.9975) with a low detection limit of 0.031 ng mL−1, and presents satisfactory specificity against some possible interfering proteins. Moreover, the method was successfully applied for CEA determination in human serum with recoveries of 80–111%, showing great promise for application in practice.

Graphical abstract: A label-free electrochemiluminescence aptasensor for carcinoembryonic antigen detection based on electrodeposited ZnS–CdS on MoS2 decorated electrode

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Publication details

The article was received on 14 Apr 2016, accepted on 11 Jun 2016 and first published on 15 Jun 2016


Article type: Paper
DOI: 10.1039/C6AY01114D
Anal. Methods, 2016,8, 5242-5247

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    A label-free electrochemiluminescence aptasensor for carcinoembryonic antigen detection based on electrodeposited ZnS–CdS on MoS2 decorated electrode

    Y. Wang, J. Cao, Y. Chen and Y. Liu, Anal. Methods, 2016, 8, 5242
    DOI: 10.1039/C6AY01114D

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