Issue 22, 2016

Real-time detection of carboplatin using a microfluidic system


A microfluidic sensor system based on a carbon nanotube-epoxy composite electrode was fabricated to allow detection of the presence of the anti-cancer drug carboplatin in healthy tissue in real time during chemotherapy. Detection of carboplatin was carried out by observing the effects of the drug on the differential pulse voltammetry of free purine bases using a novel carbon nanotube-epoxy composite electrode. In free solution these electrodes performed better than glassy carbon electrodes for oxidation of the free purine bases AMP and GMP, and than DNA-modified carbon nanotube-epoxy composite sensors for detection of carboplatin. On-line carboplatin detection was performed using a computer-controlled microfluidic platform. The methodology for on-line carboplatin detection was optimised in terms of the analysis time and to allow repeated carboplatin measurement using the same electrode. Microdialysis sampling and our microfluidic platform were combined to give a proof-of-concept system for real-time carboplatin detection with a limit of detection of 0.014 μM carboplatin in the sampled media. This paper is dedicated to Craig Lunte's pioneering work in analysis and microdialysis.

Graphical abstract: Real-time detection of carboplatin using a microfluidic system

Supplementary files

Article information

Article type
24 Jun 2016
26 Aug 2016
First published
26 Aug 2016
This article is Open Access
Creative Commons BY license

Analyst, 2016,141, 6270-6277

Real-time detection of carboplatin using a microfluidic system

T. Phairatana, C. L. Leong, S. A. N. Gowers, B. A. Patel and M. G. Boutelle, Analyst, 2016, 141, 6270 DOI: 10.1039/C6AN01446A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity